Maximum shear strain-based algorithm can predict proteoglycan loss in damaged articular cartilage
نویسندگان
چکیده
منابع مشابه
Articular cartilage proteoglycan biosynthesis and sulfation
Glucosamine (GlcN) and glucosamine sulfate (GS) have been used to treat the patients with osteoarthritis (OA) as a disease-modifying agent. Previous in vitro studies have focused on the effects of GlcN or GS on cartilage metabolism, whereas in vivo studies have investigated their potential for the treatment of OA. Although these results have raised promises of the disease-modifying effects of G...
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Proteoglycan-4 (Prg4) protects synovial joints from arthropathic changes by mechanisms that are incompletely understood. Parathyroid hormone (PTH), known for its anabolic actions in bone, increases Prg4 expression and has been reported to inhibit articular cartilage degeneration in arthropathic joints. To investigate the effect of Prg4 and PTH on articular cartilage, 16-week-old Prg4 mutant and...
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Hyaline cartilage is a strong durable material that lubricates joint movement. Due to its avascular structure, cartilage has a poor self-healing ability, thus, a challenge in joint recovery. When severely damaged, cartilage may need to be replaced. However, currently we are unable to replicate the hyaline cartilage, and as such, alternative materials with considerably different properties are u...
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Determining the depth dependence of the shear properties of articular cartilage is essential for understanding the structure-function relation in this tissue. Here, we measured spatial variations in the shear modulus G of bovine articular cartilage using a novel technique that combines shear testing, confocal imaging and force measurement. We found that G varied by up to two orders of magnitude...
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ژورنال
عنوان ژورنال: Biomechanics and Modeling in Mechanobiology
سال: 2019
ISSN: 1617-7959,1617-7940
DOI: 10.1007/s10237-018-01113-1